Name: Rosemary Extract Ursolic Acid
Botanical Name: Rosmarinus officinalis
Extract part: Dried Leaf
Active Ingredient: Ursolic Acid
Appearance: Fine Brownish Green powder
|Products Name||Activie Ingredient||Specification|
|Rosemary Leaf Extract||Carnosic Acid||5%~80%|
Rosmarinus officinalis L. from Lamiaceae family, is commonly known
as rosemary. Rosemary is a widely cultivated herbal plant that is
originated in the Mediterranean area. Rosemary is an aromatic
evergreen shrub with leaves similar to hemlock needles .The leaves
are used as a flavoring in foods and a prescription for treating
minor ailments including :gout, cough, headache, high blood
pressure, and reducing age-related memory loss.
Rosemary is used topically for preventing and treating baldness by
applying to the skin ; and treating circulation problems,
toothache, a skin condition called eczema, and joint or muscle pain
such as myalgia, sciatica, and intercostal neuralgia. It is also
used for wound healing, in bath therapy (balneotherapy), and as an
Rosemary contains a number of phytochemicals, including rosmarinic
acid, camphor, caffeic acid, ursolic acid, betulinic acid, and the
antioxidants carnosic acid and carnosol.
Rosmarinic acid is a chemical compound firstly found in Rosmarinus
officinalis which has antioxidant properties.
Another main antioxidant in rosemary is the phenolic diterpene
carnosic acid ,appears to be the main substance for general
oxidation leading to artifacts withγ-or δ-lactone structure in
extracts of Rosmarinus officinalis .
Ursolic Acid is a key component of Rosemary, that is often used in
skin care creams.Medicinal plants containing ursolic acid have been
used in folk medicine before it was known which constituents were
responsible for their therapeutic effectiveness.Ursolic acid with
the structural type of pentacyclic triterpenes allows those plants
processes several bioactivities,such as
anti-tumor,anti-inflammation and lowering hyperlipemia．
TRAIL (tumor necrosis factor (TNF)-related apoptosisinducing
ligand), a member of the TNF family, has recently been considered a
highly promising candidate as an anti-cancer drug, because it
induces apoptosis specifically in malignant or transformed cells
without any cytotoxicity toward a variety of normal cells . A
considerable number of cancer cells, however, are resistant to
apoptosis induced by TRAIL . TRAIL induces apoptosis by interacting
with two different death-inducing receptors, therefore, targeting
death receptors and their signaling molecules to trigger apoptosis
in tumor cells is an attractive concept for cancer therapy.
In 2011 scientists reported on THE JOURNAL OF BIOLOGICAL CHEMISTRY
that a component of rosemary ,Usolic Acid(UA) ,may sensitizes
TRAIL-resistant cells enhance TRAIL-induced apoptosis through ROS
and JNK-mediated up-regulation of DR4 and DR5 and down-regulation
of antiapoptotic proteins , thus rendering cancer cells more
sensitive to the cytotoxic activities of TRAIL. Considering that UA
by itself is highly safe and exhibits anticancer activities against
a wide variety of tumors in vitro and in vivo , its potential use
in combination with TRAIL should be explored. Further studies in
animals are needed to investigate the anticancer potential of UA in
combination with TRAIL.
Constituents in Rosemary extracts from Rosmarinus officinalis L
contains several compounds proven to have antioxidative function.
According to Onocology reports crude ethanolic rosemary extract
(RO) has anti-proliferative effects on human leukemia and breast
carcinoma cells. The report shows RO has substantial antioxidant
activity with RO at 1/10 and 1/5 dilutions having 8.1 and 12.6
microM Trolox equivalents, respectively. Moreover ,RO significantly
reduced NO production by lipopolysaccharide (LPS)-activated cells
in a dose-dependent manner . At 1/500 dilution, RO significantly
reduced IL-1beta (p<0.01) and COX-2 (p<0.05) mRNA expression
and non-significantly reduced TNFalpha and iNOS mRNA expression in
the LPS-activated cells.In conclusion constituents in rosemary have
shown a variety of pharmacological activities for cancer
chemoprevention and therapy in in vitro and in vivo models.
Biosci Biotechnol Biochem. reported in 2007 supercritical fluid
SF-CO2 treatment of Rosemarinus officinalis L. fresh leaves under
optimum conditions (80 degrees C at 5,000 psi) yielded 5.3% of
extract supercritical fluid extraction (SFE)-80, in which five
major active principles were identified by liquid
chromatography/mass spectrometry (LC/MS), viz., rosmarinic acid,
carnosol, 12-methoxycarnosic acid, carnosic acid, and methyl
When treated in RAW 264.7, apparent dose-dependent NO inhibition.
SFE-80 exhibited dose-dependent viability suppression and
significant tumor necrosis factor alpha (TNF-alpha) production in
Hep 3B, whereas no effect was found in Chang liver cells.
Furthermore, no effect was observed in RAW 264.7 at dosages of 3.13
to 25 microg/ml, indicating that SFE-80 exhibited a noncytotoxic
character. Conclusively, rosemary can be considered an herbal
anti-inflammatory and anti-tumor agent.
The hypolipidemic activity of leaves of rosemary (Rosmarinus
officinalis) was studied through in lab BALB/c mice treatment
experiment . The testing report was published on Journal of Biology
and Life Science in 2012 shows there was a significant decrease (P
< 0.001) in plasma total cholesterol (TC)(- 68.57%), low density
lipoprotein (LDL) (- 56.34%), and triglycerides (TG) (- 182.61%). A
significant increase in high density lipoprotein (HDL) (38.53%) was
obtained in rosemary-fed mice compared to HC mice. In another
experiment, the immunomodulatory activity of aqueous extract of R.
officinalis was evaluated in BALB/c mice for 8 weeks. Humoral
immunity against membrane proteins of sheep erythrocytes measured
by ELISA showed that IgM (Immunoglobulin M) response significantly
increased in mice fed with rosemary as compared to the control
group . IgG (Immunoglobulin G) response increased significantly at
all antibody titers, in mice fed with rosemary .
Researches proved Rosmarinus officinalis has potent
immunomodulatory and hypolipidemic activity .
Rosemary was traditionally used to help alleviate muscle pain,
improve memory, boost the immune and circulatory system,preventing
and treating baldness buy applying to the skin .Rosemary is also
used for digestion problems, including heartburn, intestinal gas
(flatulence), liver and gallbladder complaints, and loss of
In foods, rosemary is used as a spice. The leaf and oil are used in
foods, and the oil is used in beverages.
In manufacturing, rosemary oil is used as a fragrant component in
soaps and perfumes.
In the food industry ,rosemary applied as a natural antioxidants
.It is also used as an insect repellent
--Karin Schwarz, Waldemar Ternes; “Antioxidative constituents
ofRosmarinus officinalis andSalvia officinalis”;Zeitschrift für
Lebensmittel-Untersuchung und Forschung
--SUSAN CHEUNG and JOSEPH TAI; “Anti-proliferative and antioxidant
properties of rosemary Rosmarinus officinalis”;ONCOLOGY REPORTS
--Peng CH, Su JD, Chyau CC,etc; “Supercritical fluid extracts of
rosemary leaves exhibit potent anti-inflammation and anti-tumor
effects”;Biosci Biotechnol Biochem. 2007
--Fawzi Mohammad Al Sheyab,Nizar Abuharfeil,Lina Salloum; “The
Effect of Rosemary (Rosmarinus officinalis. L)Plant Extracts on the
Immune Response and Lipid Profile in Mice”;Journal of Biology and